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Saturday, June 27, 2009

Glutathione exhibits antibacterial activity and increases tetracycline efficacy against Pseudomonas aeruginosa

Thanks so much to dasjsmum for providing us with the link to the full article! :)


YaNi Zhang1 and KangMin Duan1 Contact Information

(1) Molecular Microbiology Laboratory, the College of Life Sciences, Northwest University, Xi’an, 710069, China

Received: 5 February 2009 Accepted: 5 March 2009 Published online: 26 June 2009

Abstract Glutathione (GSH) plays important roles in pulmonary diseases, and inhaled GSH therapy has been used to treat cystic fibrosis (CF) patients in clinical trials. The results in this report revealed that GSH altered the sensitivity of Pseudomonas aeruginosa to different antibiotics through pathways unrelated to the oxidative stress as generally perceived. In addition, GSH and its oxidized form inhibited the growth of P. aeruginosa.

Keywords glutathione - antibiotics - Pseudomonas aeruginosa - tetracycline - cystic fibrosis

Supported by the National Natural Science Foundation of China (Grant Nos. 30870097 and 30611120520)


*I wish I had the full text of this article. Contact your CF Center or Pulmo to see if they subscribe to this journal*

1 comment:

  1. Hi Amy

    Here's alink to the article, got it from the GSH forum: