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Thursday, January 7, 2010

American Diabetes Association Revises Diabetes Guidelines to include CF

For its 2010 Guidelines, the American Diabetes Assocation has decided to include CFRD! Nice.


December 29, 2009 — The American Diabetes Association (ADA) revised clinical practice recommendations for diabetes diagnosis promote hemoglobin A1c (A1c) as a faster, easier diagnostic test that could help reduce the number of undiagnosed patients and better identify patients with prediabetes. The new recommendations are published December 29 in the January supplement of Diabetes Care.


"We believe that use of the A1c, because it doesn't require fasting, will encourage more people to get tested for type 2 diabetes and help further reduce the number of people who are undiagnosed but living with this chronic and potentially life-threatening disease," Richard M. Bergenstal, MD, ADA president-elect of medicine & science, said in a news release. "Additionally, early detection can make an enormous difference in a person's quality of life. Unlike many chronic diseases, type 2 diabetes actually can be prevented, as long as lifestyle changes are made while blood glucose levels are still in the pre-diabetes range."


The A1c test, which measures average blood glucose levels for a period of up to 3 months, was previously used only to evaluate diabetic control with time. An A1c level of approximately 5% indicates the absence of diabetes, and according to the revised evidence-based guidelines, an A1c score of 5.7% to 6.4% indicates prediabetes, and an A1c level of 6.5% or higher indicates the presence of diabetes.


For optimal diabetic control, the recommended ADA target for most people with diabetes is an A1c level no greater than 7%. It is hoped that achieving this target would help prevent serious diabetes-related complications including nephropathy, neuropathy, retinopathy, and gum disease.


Unlike fasting plasma glucose testing and the oral glucose tolerance test, A1c testing does not require overnight fasting. Compliance with screening may therefore be improved through use of the A1c test, which can be determined from a single nonfasting blood sample.

Recommendation Changes for 2010


Specific changes in the 2010 Clinical Practice Recommendations are as follows:


A section on diabetes related to cystic fibrosis has been added to "Standards of Medical Care in Diabetes." New evidence has shown that early diagnosis of cystic fibrosis-related diabetes and aggressive treatment with insulin have narrowed the gap in mortality between patients with cystic fibrosis with and without diabetes and have eliminated the sex difference in mortality rates. New recommendations for the clinical management of cystic fibrosis-related diabetes, based on a 2009 consensus conference, will be published in 2010 in a consensus report.


Revision of the section "Diagnosis of Diabetes" now includes the use of the A1c level for diabetes diagnosis, with a cutoff point of 6.5%.


The section formerly named "Diagnosis of Pre-diabetes" is now named "Categories of Increased Risk for Diabetes." Categories suggesting an increased risk for future diabetes now include an A1c range of 5.7% to 6.4%, as well as impaired fasting glucose and impaired glucose tolerance levels.


Revisions to the section "Detection and Diagnosis of GDM [Gestational Diabetes Mellitus]" now include a discussion of possible future changes in this diagnosis, according to international consensus. Screening recommendations for gestational diabetes are to use risk factor analysis and an oral glucose tolerance test, if appropriate. Women diagnosed with gestational diabetes should be screened for diabetes 6 to 12 weeks postpartum and should have subsequent screening for the development of diabetes or prediabetes.


Extensive revisions to the section "Diabetes Self-Management Education" are based on new evidence. Goals of diabetes self-management education are to improve adherence to standard of care, to educate patients regarding appropriate glycemic targets, and to increase the percentage of patients achieving target A1c levels.


Extensive revisions to the section "Antiplatelet Agents" now reflect evidence from recent trials suggesting that in moderate- or low-risk patients, aspirin is of questionable benefit for primary prevention of cardiovascular disease. The revised recommendation is to consider aspirin treatment as a primary prevention strategy in patients with diabetes who are at increased cardiovascular risk, defined as a 10-year risk greater than 10%. Patients at increased cardiovascular risk include men older than 50 years or women older than 60 years with at least 1 additional major risk factor.


Fundus photography may be used as a screening strategy for retinopathy, as described in the section "Retinopathy Screening and Treatment." However, although high-quality fundus photographs detect most clinically significant diabetic retinopathy, they should not act as a substitute for an initial and dilated comprehensive eye examination. Retinal examinations should be carried out annually or at least every 2 to 3 years among low-risk patients with normal eye examination results in the past.


Extensive revisions to the section "Diabetes Care in the Hospital" now question the benefit of very tight glycemic control goals in critically ill patients, based on new evidence.
Extensive revisions to the section "Strategies for Improving Diabetes Care" are based on newer evidence. Successful strategies to improve diabetes care, which have resulted in improved process measures such as measurement of A1c levels, lipid levels, and blood pressure, include the following:


Delivery of diabetes self-management education.


Adoption of practice guidelines developed with participation of healthcare professionals and having them readily accessible at the point of service.


Use of checklists mirroring guidelines, which help improve adherence to standards of care.
Systems changes, including providing automated reminders to healthcare professionals and patients and audit and feedback of process and outcome data to providers.


Quality improvement programs, in which continuous quality improvement or other cycles of analysis and intervention are combined with provider performance data.


Practice changes, which may include access to point-of-care A1c testing, scheduling planned diabetes visits, and clustering dedicated diabetes visits into specific times.


Tracking systems with either an electronic medical record or patient registry to improve adherence to standards of care.


Availability of case or (preferably) care management services using nurses, pharmacists, and other nonphysician healthcare professionals following detailed algorithms under physician supervision.


"The most successful practices have an institutional priority for quality of care, involve all of the staff in their initiatives, redesign their delivery system, activate and educate their patients, and use electronic health record tools," the guidelines authors conclude. "It is clear that optimal diabetes management requires an organized, systematic approach and involvement of a coordinated team of dedicated health care professionals working in an environment where quality care is a priority."


Diabetes Care. December 29, 2009; January 2010 Supplement.

4 comments:

  1. way cool. do you know if the cff has an opinion as to the efficacy of a1c testing vs. OGTT for diagnosing early or borderline CFRD? i was concerned about diabetes earlier this year (as was my doctor), but she ran an a1c b/c that's what my tx team wanted/required. it came back completely normal so she didn't order an OGTT. it's been over a year since i've had one of those, but i feel like maybe that's okay if my a1C was fine. thoughts? (and no, i'm not asking for medical opinions...just friendly advice ;))

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  2. Hey girlie, great questions! I think it's important to look at both the A1C as well as the 2 hour fasting OGTT.

    A1C looks over a longer period of time. So if you're recently diabetic, the A1C might still be in a normal range.

    The OGTT looks at how your pancreas is functioning right now as well as what impact inflammation is having on your body (remember CFRD is often a combo of a lazy pancreas and decreased glucose sensitivity due to inflammation).... which I think is very important. As you know, being aggressive with treating diabetes is critical to stave off infections (I know you've been having them frequently).

    I know an OGTT can be a pain to do, but I think for your health it's critically important.

    At the very least, you'll find out you're A-OK and you won't have to worry about it. :)

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  3. Hey Amy, I've lost your email to my old computer :) Would you mind sending me your contact info to ronnie@cysticlife.org?

    Thanks cyster!

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  4. Hey Ronnie - you can reach me at saveferris2009@gmail.com

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