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Monday, March 28, 2011

Inhaled PDE5's treat CF

Never realized the plan was to nebulize cialis or levitra - always thought we would just take them as a pill. So interesting....

Expert Opin Investig Drugs. 2011 Mar 24. [Epub ahead of print]

Inhaled phosphodiesterase type 5 inhibitors for cystic fibrosis: a new therapy for systemic disease?

University of Medicine and Pharmacy "Gr.T.Popa" Iasi, Department of Internal Medicine II-Pulmonary Disease, Pulmonary Disease University Hospital, 30 Dr I Cihac Str, 700115 Iasi, Romania +40 232 
239408 ; +40 232 270918 ; sabina.antonela.antoniu@pneum.umfiasi.ro.


Cystic fibrosis is a rare disease characterized by abnormalities in chloride and sodium transmembrane transportation due to various mutations in the cystic fibrosis transmembrane regulator (CFTR) gene, F508del being the most commonly found. Corrective therapies for this defect are currently under investigation and PDE5 inhibitors such as sildenafil or vardenafil were found to improve CFTR activity in vitro as well as in vivo. This paper evaluates a study investigating the effects of inhaled PDE5 inhibitors in an animal model of F508del cystic fibrosis, demonstrating that in this new formulation, such compounds are also able to improve CFTR function. Such results support the further development of this therapy for a systemic disease such as cystic fibrosis, provided several issues are addressed.
PMID: 21434839 [PubMed - as supplied by publisher

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