Association between genotype and pulmonary phenotype in CFers

J Cyst Fibros. 2011 Feb 25. [Epub ahead of print]

Association between genotype and pulmonary phenotype in cystic fibrosis patients with severe mutations.

Geborek A, Hjelte L.

Abstract

BACKGROUND: Despite numerous studies a clear relationship between genotype and pulmonary phenotype has not been established within the group pancreatic insufficient cystic fibrosis (CF) patients. We studied the relationship between class I and class II mutations and pulmonary function in Swedish patients with known CFTR functional classification.

METHODS: 170 CF patients with two class II mutations, 18 with two class I mutations and 78 with a combination of class I and II mutations were included in the study. Spirometry was performed when patients were in an optimal clinical condition.

RESULTS: Patients with two class I mutations had lower lung function (FEV(1) and FVC) compared to the group with either a combination of class I and II mutations or two class II mutations.

CONCLUSION: CF patients carrying two class I mutations risk developing more severe lung disease compared to patients with at least one class II mutation.

Copyright © 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.