This is an article and a subject of particular interest to me, so I'm going to do what I can to try to get a hold of the full text of the article. I have never heard of CCB's being used with levo, but I'm dying to know what the outcome is.
If you have any info on this let me know.
Microbiological appraisal of levofloxacin activity against Pseudomonas aeruginosa biofilm in combination with different calcium chanel blockers in vitro.
Elkhatib WF, Haynes VL, Noreddin AM.
Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota Duluth, Duluth, MN 55812, USA.
Chronic multi-drug resistant Pseudomonas aeruginosa infections among hospitalized elderly patients are nearly epidemic in some institutions and biofilms are now recognized as the root cause of such chronic infections such as with cystic fibrosis patients. We address the potential risks and advantages of combining commonly prescribed calcium channel blockers (CCBs) with the fluoroquinolone levofloxacin in the treatment of P. aeruginosa biofilms by using in vitro real-time monitoring of biofilm growth/inhibition over time. while mibefradil and diltiazem appear to be strongly antagonistic toward antimicrobial activity of levofloxacin, amlodipine and bepridil appear to have significant synergistic effects.
Publication Types:
* Research Support, Non-U.S. Gov't
PMID: 19423465 [PubMed - in process]
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