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Tuesday, December 22, 2009

Comparison of inhaled mannitol, daily rhDNase, and a combination of both

Comparison of inhaled mannitol, daily rhDNase, and a combination of both in children with cystic fibrosis: a randomised trial.

Minasian CC, Wallis C, Metcalfe C, Bush A.Royal Brompton Hospital & Imperial College, London, United Kingdom;

BACKGROUND: Osmotic agents, such as inhaled dry powder mannitol may increase mucociliary clearance (MCC) by rehydrating the airway-surface liquid (ASL) and thus act as disease-modifying treatments in cystic fibrosis (CF). This is the first therapeutic trial of inhaled mannitol in children with CF. We have compared it to human recombinant deoxyribonuclease (rhDNase), the current best established mucolytic therapy.

METHODS: 38 children were recruited to an open crossover study. Subjects underwent an initial bronchial provocation challenge with dry powder mannitol. Those children with a negative challenge were randomly allocated to one of three consecutive twelve-week treatment blocks (inhaled mannitol alone, nebulised rhDNase alone and mannitol + rhDNase). The primary outcome was forced expiratory volume in 1 second (FEV(1)). A number of secondary outcome measures were also studied.

RESULTS: Twenty children completed the study. Bronchoconstriction and cough associated with mannitol administration contributed to the high attrition rate. The mean increase in FEV(1) following 12 weeks of treatment was 0.11 litres (6.7%) (p=0.055) for mannitol alone, 0.12 litres (7.2%) (p=0.03) for rhDNase alone & 0.03 litres (1.88%) (p=0.67) for rhDNase and mannitol. None of the secondary clinical outcomes were statistically significantly different between treatments.

CONCLUSIONS: Inhaled mannitol was at least as effective as rhDNase after 3 months treatment. There was a marked individual variation in tolerance to mannitol and in response to therapy however. Children who do not respond to rhDNase many benefit from a trial of inhaled mannitol. The combination of mannitol and rhDNase was not useful.

The trial was registered with ClinicalTrials.gov (Identifier NCT00117208).


  1. hey its Nicole.

    Can you tell me how you post your articles? I have the hardest time and it takes alot of work and formatting, then reformatting. I have some articles I want to post and there has to be an easier way than what I am doing.


  2. Hey girl I just copy and paste and put a few spaces in the big blob of paragraph that I usually have.

    If it's an article from a newpaper, etc. I do the "print" view first and then copy from there :)