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Tuesday, February 2, 2010

Vitamin D therapy in CF

As you may or may not know, adequate vitamin D is ESSENTIAL to calcium absorption and immune system function.

Because Vitamin D is fat soluable, many CFer's are defficient.

Do you know what your last Vitamin D test showed about your levels?

J Cyst Fibros. 2010 Jan 28.

Transient effectiveness of vitamin D(2) therapy in pediatric cystic fibrosis patients.

Green DM, Leonard AR, Paranjape SM, Rosenstein BJ, Zeitlin PL, Mogayzel PJ Jr.

Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

BACKGROUND: The effectiveness of current treatment recommendations for vitamin D insufficiency in children with CF is unknown. Therefore, we assessed the effectiveness of vitamin D(2) 50,000IU once daily for 28days for vitamin D insufficiency.

METHODS: Retrospective chart review of pediatric CF patients from 2006-2008. Vitamin D(2) 50,000IU daily for 28days was given to patients with 25-OHD <30ng/mL and repeat 25-OHD levels were obtained after completion of therapy.

RESULTS: One hundred forty-seven levels from 97 individuals were assessed. Success of treatment was 54% (n=80/147). Seventeen of 39 patients (43%) followed for an additional 6-18months were able to maintain levels of >/=30ng/mL.

CONCLUSIONS: Vitamin D(2) 50,000IU daily for 28days was effective in correcting vitamin D insufficiency in approximately 50% of subjects. However, almost half of successfully treated patients were unable to maintain normal 25-OHD levels >6months after completion of therapy, implying that this effect is transient.

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