One-year glargine treatment can improve lung disease in CF and early glucose derangements.

One-year glargine treatment can improve the course of lung disease in children and adolescents with cystic fibrosis and early glucose derangements.

Pediatr Diabetes. 2009 Jan 14;

Authors: Mozzillo E, Franzese A, Valerio G, Sepe A, De Simone I, Mazzarella G, Ferri P, Raia V

Mozzillo E, Franzese A, Valerio G, Sepe A, De Simone I, Mazzarella G, Ferri P, Raia V. One-year glargine treatment can improve the course of lung disease in children and adolescents with cystic fibrosis and early glucose derangements. Pediatric Diabetes 2008. Background: Diabetes increases morbidity and mortality in cystic fibrosis (CF) patients, but several studies indicate that also prediabetic status may have a potential impact on both nutrition and lung function. Objective: To evaluate the effect of glargine on the clinical course in CF patients with early glucose derangements. Methods: CF population was screened for glucose tolerance. CF patients with age >10 yr were screened with fasting hyperglycemia (FH). CF patients with age >10 yr without FH and those with age <10 p =" 0.017)." p =" 0.01)" p =" 0.003)">

PMID: 19207231 [PubMed - as supplied by publisher]